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Monophasic 21 day pillshas the same amount of hormone in it, and you take one pill every day for 21 days, and then have a seven day break, if you wish before starting the next pack of pills. In the 150 mg bupropion arm, 2 patients 26 experienced a grade 3 event and 1 patient in the 300 mg bupropion arm 14 and placebo arm 13 experienced a grade 3 event related to treatment. This medicine can cause serious side effects in patients with heart problems. At first, only thinning of hair is noticed, not clear baldness.